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Daicel Corporation

GRANFILLER_D

GRANFILLER-D is jointly developed by DAICEL Group and NICHIRIN-Chem.

It was originally designed to achieve compatiblity between high tablet hardness and rapid disintegration in the direct compression method of tablet production.

Benefits and strengths :

- High performance due to sophisticated co-processed formulation

- Simple manufacturing process (weighing , mixing , tableting...etc.)

- No need for special equipment , only conventional equipment

Orally disintegrating tablets (ODTs) have attracted attention as an advanced dosage form which is better than conventional capsules and tablets for patient compliance and adherence.

Previously, various materials and techniques have been developed to achieve ODTs such as lyophilization.

However, ODTs can also be produced using the direct compression method with conventional equipment and a simple process.

GRANFILLER-D is a state-of-the-art co-processed excipient for direct compression ODTs.

With unique ideas and technical support, Daicel can provide the best solution for you.


Regulatory

All components of GRANFILLER-D are listed on JP, USP and EP.

GNF-D211 is listed on DMF and GNF-D215 will be listed next.


Physical property Indormation

Two grades of GRANFILLER-D 

with different particle sizes are available.

*1 Measured by dry laser diffraction / light scattering particle counter.


Measurements of particle size distribution by dry laser diffraction


Performance of placebo tablets

GRANFILLER-D GNF-D211 / GNF-D215 are compatible

with " 100N tablet hardness " and " 20 sec oral disintegration time " in 250mg  8mm tablet size.

GRANFILLER-D can achieve excellent disintegration even under high compression force.


Contribution of unique Granulation to compaction property

Applying a unique wet granulation method, GRANFILLER-D improves compaction property compared to a simple mixture of individual ingredients.



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